​Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface

Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface

Biomaterials are those materials that interact with biological systems, often used in medical applications to augment or replace a natural function. Biomaterials could be natural or synthetic, alive or lifeless, and usually made of multiple components. All biomaterials when implanted into the body trigger an immune response, so, when evaluating biomaterial, it is necessary to consider the effects of implants on immune cells.

The elements with (n-1) d10ns1−2 valence electronic structures are called ds-block elements, which have excellent biological properties, such as antibiosis, osteogenesis, etc. Thus, they are widely used in biomaterial fields, especially in the orthopedic implants field.

A new study published on Bioactive Materials in 2021 investigated the rule of ds-block elements in the immune response and the involved mechanisms by introducing the three most widely used ds-block elements, copper, zinc, and silver on titanium substrate.

Results of this study showed that comparing with the titanium sample, the implanted samples could up-regulate the anti-inflammation and down-regulate the inflammation. The trend of anti-inflammatory effects of macrophages was in correlation with the number of valence electrons of ds-block elements. The co-culture experiments of macrophages and bone marrow mesenchymal stem cells showed that these two kinds of cells could enhance the anti-inflammation and osteogenesis of samples by the paracrine manner of PGE2. Moreover, molecular biology experiments indicate that the PGE2-related signaling pathway may contribute to the anti-inflammatory response and osteogenic differentiation.

This research provides a new sight into the selection of the ds-block elements in the design of the biomaterial surface.

Anogen’s human IL-4, IL-6, and TNF-α ELISA kits were used in this research to conduct an immunological evaluation in vitro study. Anogen provides hundreds of high-quality antibodies and ELISA to support researches in life science and medical science,

For more information, please visit Anogen website: https://www.anogen.ca

Reference:

Chen L, Wang D, Qiu J, Zhang X, Liu X, Qiao Y, Liu X. Synergistic effects of immunoregulation and osteoinduction of ds-block elements on titanium surface. Bioact Mater. 2020 Aug 14;6(1):191-207. doi: 10.1016/j.bioactmat.2020.08.001. PMID: 32913928; PMCID: PMC7452063.