Description: Mouse monoclonal antibody to human platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa)
Purification: Protein G affinity purified
Product Type: Primary antibody
Target Protein: Human platelet membrane glycoprotein IIb/IIIa
Immunogen: Human platelet suspension
Fusion Myeloma: Sp2/0-Ag14
Specificity: The mAb reacts with GPIIb/IIIa.
Species Reacitvity: Human, others not tested
Host / Isotype: Mouse, IgG1 Kappa
Formulation: Lyophilized from a solution in 0.01M PBS, pH 7.2
Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Storage: Store at -20oC
Research Area: Hematology, blood coagulation
Human platelet membrane glycoprotein Glycoprotein IIb/IIIa (GP IIb/IIIa) is a dominate receptor on the platelet membrane with very high molecular weight (>200kDa). After the platelet is activated, the GP IIb/IIIa receptor complex changes conformation and binds to fibrinogen in blood circulation with high affinity. The activation of platelets is initiated locally when the endothelial layer is wounded and the platelets are exposed to the collagen underneath the endothelium. The fibrinogen aggregates with platelets when binding to the GP IIb/IIIa receptor on platelets, thus primary haemostasis (Platelet clot) is formed.
ELISA: The mAb is reactive to platelet coated ELISA plate.
Western Blot: The antibody reacts with a band corresponding to the position of GPIIIa on the blot transferred with gel separated platelet membrane glycoproteins.
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
|Product Specificity||mAb anti-Human GP IIb/IIIa, 474|