Recombinant Human IFN-γ Protein

Description

Recombinant Human IFN-γ Protein is derived from the human IFN-γ gene and recombinantly expressed in E. coli. The gene is located on human chromosome 12q15. Belonging to the Type II interferon family, IFN-γ is a secreted protein primarily produced by activated natural killer cells, CD4⁺ and CD8⁺ T lymphocytes. IFN-γ not only exhibits antiviral activity but also plays critical immunomodulatory roles: it acts as an effective activator of macrophages, exerts antiproliferative effects on transformed cells, and enhances the antiviral and antitumor effects of Type I interferons. IFN-γ receptors are present on most immune cells, which respond to IFN-γ signaling by increasing the surface expression of Class I MHC (major histocompatibility complex) proteins, enabling antigen presentation to helper T cells (CD4⁺). IFN-γ is essential for innate and adaptive immunity against viral or intracellular bacterial infections, as well as for tumor control. Abnormal IFN-γ expression has also been linked to several auto-inflammatory and autoimmune diseases.

• Storage solution: 20 mM PBS，pH=7.4.

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