Description: Mouse monoclonal antibody to human α-synuclein
Purification: Protein G affinity purified
Product Type: Primary antibody
Target Protein: Human α-synuclein
Immunogen: Recombinant human α-synuclein (1-140 aa) expressed in E. coli.
Fusion Myeloma: Sp2/0-Ag14
Specificity: This antibody recognizes human α-synuclein epitope YQDYEP(E).
Species Reacitvity: Human
Host / Isotype: Mouse, IgG2a Kappa
Formulation: Lyophilized from a solution in 0.01M PBS pH7.2
Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Storage: Store at -20oC
Research Area: Parkinson’s disease, neurodegenerative diseases
α-synuclein is a protein of unknown function. It is mainly found in neural tissue. There is a lipid-binding motif similar to that of Apolipoproteins on its N-terminal. A hydrophobic region that is the non-beta component found in amyloid aggregation in Alzheimer’s disease is located at the central region of the protein. The abnormal aggregation of α-synuclein on brain tissue is called Lewy bodies, which are found in Parkinson’s disease, dementia and multiply system atrophy. Mutated α-synuclein gene is found to be associated with rare familial form of Parkinson’s disease.
ELISA: The antibody reacts with recombinant α-synuclein.
Western Blot: Detect recombinant α- synuclein (α-SYN) using antibody 4B4 at 5μg/mL dilution.
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
|Product Specificity||mAb anti-Human α-Synuclein, 4B4|