Matched Antibody Pairs to Human Infectious Agents

mAb anti human PD-L1 clone 12B4, Tracer (Biotin Labeled)

Catalogue #: MO-L40044TB

$430.00

In stock

Biotin labeled mouse monoclonal antibody (mAb) to human programmed death- ligand 1 (PD-L1), or biotin labeled mouse mAb to B7H1, or biotin labeld mouse mAb to human CD274. 0.1mL 

Description

Details

Description: Biotin labeled mouse monoclonal antibody (mAb) to human programmed death- ligand 1 (PD-L1), or biotin labeled mouse mAb to B7H1, or biotin labeld mouse mAb to human CD274.  

Purification: Protein G affinity purified

Product Type: Tracer antibody in matched antibody pair, biotin conjugated

Target Protein: Human programmed death-ligand 1 (PD-L1), also known as B7H1 or CD274.

Immunogen: Human cell expressed recombinant PDL-1 (Phe19-Arg238) with poly-histidine tag at C-terminus.

Fusion Myeloma: Sp2/0-Ag14

Specificity: Reactive with human programmed death-ligand 1 (PD-L1).

Species Reactivity: Human, others not tested.

Host / Isotype: Mouse, IgG1 Kappa

Formulation: In 0.01M PBS, pH 7.2, containing 0.5% gelation

Storage:Store at -20oC. Avoid repeated freeze/thaw cycles after reconstitution.

Research Area: Immunosuppression. Cancer immunotherapy.

Background: 

PD-L1, a 40KD transmembrane protein, is a ligand of immune checkpoint protein Programmed Death-1 (PD-1). During T-cell receptor signalling, the binding of PD-L1 to PD-1 transmits an inhibitory signal to activated T-cells to decrease their proliferation. PD-L1 is also believed to play a role in the generation and regulation of Treg cells, and in the enhancement of Treg cell function. PD-L1/PD-1 pathway is important to immune suppression, such as self-tolerance, suppression of immune-rejection during pregnancy and allograft, and immune evasion by cancers. Upregulation of PD-L1 has been found to be associated with many cancer types. For example, increased PD-L1 expression has been shown to be related to tumor aggressiveness and higher mortality in patients with renal cell carcinoma, and related to significantly poorer prognosis and lower intraepithelial CD8+ T-lymphocyte count in patience with ovarian cancer. Antibodies that block the PD-L1 /PD-1 pathway have been extensively studied in clinical trials, and some have been approved as immunotherapy for cancer.

Application:

Sandwich ELISA:Biotin labelled anti-PD-L1 clone 12B4, when used in combination with clone 15G3 (Cat. NO.: MO-L40044N) coated plate, can detect human cell expressed PD-L1 in Sandwich ELISA application

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product Specificity mAb anti human PD-L1 clone 12B4, Tracer (Biotin Labeled)
Application EIA
Size 0.1 mL
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