mAb anti-Human HLA-ABC, LY5.1

Description: Mouse monoclonal antibody to human HLA-ABC (Class I HLA heavy chain). 

Purification: Protein G affinity purified

Product Type: Primary antibody

Target Protein: Human HLA-ABC (Class I HLA heavy chain)

Immunogen: Purified class I HLA complex

Fusion Myeloma: Sp2/0-Ag14

Specificity: This monoclonal antibody reacts with human HLA-ABC.

Species Reactivity: Human, others not tested.

Host / Isotype: Mouse, IgG1 Kappa

Formulation: Lyophilized from a solution in 0.01M PBS, pH 7.2

Reconstitution: Double distilled water is recommended to reconstitute the antibody.

Storage: Store at -20^oC

Research Area: Haematology, Immunology

Background: 

Human leukocyte antigen (HLA) is the antigen binding, membrane bound a chain of major histocompatibility complex I (MHC1).  While the small b chain is the invariable beta 2 microglobulin, the a chain has three major isoforms (HLA-A, HLA-B, HLA-C) that are encoding by different loci on chromosome 6 and each of the isoforms has a highly variable region that resembles Fab on immunoglobulin.  The HLA-ABC antibody reacts with a common epitope shared by HLA-A, HLA-B and HLA-C.

Application: 

Western Blot

Immuno-precipitation

Immunohistochemistry (IHC)

Immunofluorescence

References:

Bushkin, Y., et. al. A New HLA-Linked T Cell Membrane Molecule, Related to the β Chain of the Clonotypic Receptor, is associated with T3.  J. Exp. Med. (1986), 164(August):458-473.

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.