mAb anti-Amyloid β Peptide 40, CV9 7B10, Detector

Description: Mouse monoclonal antibody to C-terminus of amyloid beta peptide 40 (Aβ40)

Purification: Protein G affinity purified

Product Type: Primary antibody-Detection antibody in matched antibody pair

Target Protein: C-terminus of amyloid beta peptide 40

Immunogen: KLH conjugated to a short peptide (GLMVGGVV) with amino acid sequence corresponding to the C-terminal of Aβ40

Fusion Myeloma: Sp2/0-Ag14

Specificity: This antibody recognizes the C-terminal sequence (GLMVGGVV) of Aβ40 and full length Aβ40. The antibody showed very weak to none cross-reactivity with Ab43 and Ab42.

Species Reacitvity: Human and other primates; mouse, rat

Host / Isotype: Mouse, IgG1 Kappa

Formulation: Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL. 

Storage: Store at -20^oC

Research Area: Aging and neurodegenerative diseases

Background:  

Aβ40 and Aβ42 are the two major amyloid peptides formed after cleavage of amyloid precursor protein. In blood and cerebrospinal fluid, the concentration of Aβ40 is about 10 timers higher than that of Aβ42. Aβ40 is the main component in the amyloid deposit of vascular amyloid angiopathy. Detection of Aβ40 is useful for the predication of Alzheimer’s disease.  Lower than normal Aβ42/Aβ40 ratio in cerebrospinal fluid was found to be associated with increased risk of mild cognitive impairment and Alzheimer’s disease.

Application: 

ELISA:  In combination with capturer anti-amyloid peptide N-terminal antibody (mAb clone NT 5B8, Cat. No.: MO-M40094D), the antibody can detect Aβ40 in Sandwich ELISA assay. 

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.