pAb Rabbit anti-Phospho-Bcl-xL (Thr115)

Description: Rabbit anti-Threonine 115 phosphorylated Bcl-xL polyclonal antibody

Purification: Protein G affinity purified

Product Type: Primary antibody

Target Protein: Threonine 115 phosphorylated Bcl-xL

Immunogen: A synthetic peptide (TSQLHIT_pPGTAY) derived from Threonine 115 phosphorylated Bcl-xL, conjugated with KLH for immunization

Specificity: This antibody is reactive to the synthetic Bcl-xL peptide (TSQLHIT_pPGTAY).

Species Reacitvity: Human and other species with consensus Bcl-xL peptide (TSQLHIT_pPGTAY)

Source: Rabbit

Formulation: Lyophilized in pH 7.4, 0.01M PBS

Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Storage: Store at -20^oC

Research Area: Life science research, apoptotic signalling

Background:

Bcl-xL is a prosurvival factor in the Bcl-2 family. It is a mitochondrial outer membrane protein that regulates the voltage-dependent anion channels (VDAC), and controls the production of reactive oxygen species and the release of cytochrome C. Bcl-xL gene knock-out resulted in embryonic lethality in animal model due to neuronal apoptosis and erythroid apoptosis. Bcl-xL is believed to be involved with the survival and differentiation of erythroid cells, iron metabolism and hemoglobin synthesis.  

Application:

ELISA: The antibody, when 1:10,000 - 1:100,000 diluted, can detect the Threonine 115 phosphorylated Bcl-xL coated on ELISA plate.

Other applications have not been evaluated. 

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.